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CAS RN: | 產品號碼: P3244
Pyridostatin Pentatrifluoroacetate
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純度/分析方法: >95.0%(HPLC)(qNMR)
别名:
- 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide Pentatrifluoroacetate
- 4-(2-Aminoethoxy)-N,N'-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide Pentatrifluoroacetate
文件：
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| 產品號碼 | P3244 |
純度/分析方法 
|
>95.0%(HPLC)(qNMR) |
| 分子式 / 分子量 | C__3__1H__3__2N__8O__5·5C__2HF__3O__2 = 1,166.76 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Frozen (<0°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic,Heat Sensitive |
| 相關CAS RN
|
1085412-37-8&2758498-85-8 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2933.49-000 |
Application
Pyridostatin Pentatrifluoroacetate: A Ligand for Stabilization of Guanine Quadruplexes in Cells
Guanine quadruplexes (G4s) are non-Watson-Crick four-stranded nucleic acid structures held together by noncanonical G-G base tetrads. Recent studies indicate their existence in vivo and their involvement in various biological processes.1) Pyridostatin pentatrifluoroacetate (RR82 pentatrifluoroacetate) stabilizes the G4s with high selectivity relative to double-stranded DNA and RNA, and can be used in to inhibit telomerase activity.2) Pyridostatin has been reported to promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.3-5) (The product is for research use only.)
References
- 1) G-quadruplex interacting small molecules and drugs: from bench toward bedside (a review)
- 2) A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
- 3) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
- 4) G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
- 5) Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours
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