In recent years, cyclodextrin scaffolds has been applied not only in the field of functional materials such as self-repairing polymers,¹⁾ but also DDS as siRNA carrier.²⁾ TCI offers extensive lineup of mono-functionalized cyclodextrins based on the regioselective functionalization technology of β-cyclodextrins. In particular mono-6-O-(p-toluenesulfonyl)-β-cyclodextrin (Product No. M3398), one of the typical building blocks, has achieved high purity of at least 95% by HPLC by significantly reducing the content of multisubstituted byproducts. In addition, cyclodextrin structures can be introduced into target molecules by using click reactions utilizing the azide group of 6A-azido-6A-deoxy-β-cyclodextrin (Product No. A3454)³⁾ and condensation reactions utilizing the amino group of 6A-amino-6A-deoxy-β-cyclodextrin (Product No. A3453), making it suitable for use in a variety of fields.

Scale-up synthesis and high purification of each derivatives are also available, so please contact us.

References

• 1) Multistimuli-Responsive Intrinsic Self-Healing Epoxy Resin Constructed by Host–Guest Interactions
  • Z. Hu, D. Zhang, F. Lu, W. Yuan, X. Xu, Q. Zhang, H. Liu, Q. Shao, Z. Guo, Y. Huang, Macromolecules 2018, 51, 5294.
• 2) Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma
  • S. Hu-Lieskovan, J. D. Heidel, D. W. Bartlett, M. E. Davis, T. J. Triche, Cancer Res. 2005, 65, 8984.
• 3) Voltage-Responsive Vesicles Based on Orthogonal Assembly of Two Homopolymers
  • Q. Yan, J. Yuan, Z. Cai, Y. Xin, Y. Kang, Y. Yin, J. Am. Chem. Soc. 2010, 132, 9268.

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Related Product Category Pages

• Cyclodextrins
• Cyclodextrins [Functional Oligosaccharides]
• Cyclodextrins (for DDS)

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