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Non-Receptor Tyrosine Kinase (Non-RTK) Inhibitors
Non-RTKs are cytosolic TK enzymes that doesn't have a transmembrane domein. Non-RTK's activity is regulated by other factors on cell surface or in the cytoplasm and it transmits signals. Human non-RTK family includes ABL, ACK, CSK, FAK, FES, FRK, JAK, SRC, TEC and SYK. Mutations in a gene for non-RTKs (including BCR-ABL) can result in an aberrant activity of this enzyme; pathologically increased activity of non-RTK may be responsible for growth of malignances, the induction of drug-resistance, and formation of metastasis. Non-RTKs are regarded as important targets in development of anti-tumor agents.
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