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CAS RN: 665-66-7 | Product Number: A0588

1-Adamantanamine Hydrochloride

Chemical Structure of 1-Adamantanamine Hydrochloride
×
× 1-Adamantanamine Hydrochloride

Purity: >99.0%(T)
Synonyms:
  • 1-Aminoadamantane Hydrochloride
  • Amantadine Hydrochloride
  • 1-Adamantylamine Hydrochloride
Product Documents:
SDS | Specifications | C of A & Other Certificates | Analytical Charts

General Information | Specifications & Properties | Safety & Regulations | Applications & Literature

Supplemental Product Information

Explanatory notes for this page

25G
$45.00
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250G
$205.00
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Supplemental Product Information:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number A0588
Purity / Analysis Method >99.0%(T)
Molecular Formula / Molecular Weight C__1__0H__1__7N·HCl = 187.71 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 665-66-7
Related CAS RN 768-94-5
Reaxys Registry Number 4198854
PubChem Substance ID 87562172
MDL Number

MFCD00074723
Specifications
Appearance White to Almost white powder to crystal
Purity(Nonaqueous Titration) min. 99.0 %
Purity(Argentometric Titration) min. 99.0 %
Solubility in Water almost transparency
NMR confirm to structure
Properties (reference)
Melting Point 360 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# AU4375000
Transport Information:
HS Number 2921.30.5000
Application
1-Adamantanamine Hydrochloride: A Dopamine Receptor Agonist and an Anti-Influenza A Virus Agent

1-Adamantanamine hydrochloride and its free base [A2318] are dopamine receptor agonists and anti-influenza A virus agents, similarly rimantadine hydrochloride [R0070]. 1-Amantadine was originally developed as an antiviral agent. One day, a single patient noticed relief in her Parkinson’s disease symptoms after taking amantadine for a flu infection, and this observation led to a new drug indication.1)
These mechanisms of action are not fully understood. However, there is evidence to suggest that 1-adamantanamine act as a dopamine receptor agonist by enhancing the synthesis and release of dopamine from nerve cells and delaying the reuptake into synaptic vesicles.2,3)
In addition, 1-adamantanamine inhibits the replication of influenza A viruses by preventing the release of infectious viral RNA into the host cell nucleus by interfering with the function of the transmembrane of the viral M2 protein.4,5) (The product is for research purpose only.)

References


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