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CAS RN: 106941-25-7 | Product Number: A2322
Adefovir
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Purity: >98.0%(T)(HPLC)
Synonyms:
- [2-(6-Aminopurin-9-yl)ethoxymethyl]phosphonic Acid
- 9-[2-(Phosphonomethoxy)ethyl]adenine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25G |
$182.00
|
Contact Us | 1 | 8 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A2322 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__2N__5O__4P = 273.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 106941-25-7 |
| Reaxys Registry Number | 3561094 |
| Merck Index (14) | 151 |
| MDL Number | MFCD00866943 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 284 °C |
GHS
Related Laws:
| RTECS# | SZ6563500 |
Transport Information:
| HS Number | 2933.59.9500 |
Application
An Acyclic Nucleotide Analog with Activity against DNA virus
Adefovir (9-(2-phosphonylmethoxyethyl)adenine) is an acyclic nucleotide analog with activity against DNA virus such as human hepatitis B virus (HBV), and an active metabolite of adefovir dipivoxil [A2414] which was developed for clinical use.1) There are reports that adefovir inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.2-5) (The product is for research purpose only.)
References
- 1) Clinical pharmacokinetics of the antiviral nucleotide analogs cidofovir and adefovir (a review)
- 2) Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells
- 3) Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ
- 4) Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro
- 5) Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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