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CAS RN: 6066-82-6 | Product Number: B0249

N-Hydroxysuccinimide [Coupling Reagent for Peptide]


Purity: >98.0%(GC)(T)
Synonyms:
  • HOSu
  • NHS
Documents:
25G
$83.00
4   3   ≥40 
100G
$207.00
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Product Number B0249
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__4H__5NO__3 = 115.09 
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 6066-82-6
Reaxys Registry Number 113913
PubChem Substance ID 87563364
SDBS (AIST Spectral DB) 5311
MDL Number

MFCD00005516

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 98.0 to 102.0 °C
Solubility in Dioxane lmost transparency
NMR confirm to structure
Properties (reference)
Melting Point 100 °C
Solubility in water Soluble
Solubility (soluble in) Dioxane
GHS
Related Laws:
Transport Information:
HS Number 2928.00.5000
Application
An Additive for Condensation Reactions

Experimental procedure: A mixture of 1 (3.8 g, 17.5 mmol) and N-hydroxysuccinimide (3.0 g, 26.2 mmol) in CH2Cl2 (100 mL) and THF (50 mL) at 0 °C is treated with EDC・HCl (5.0 g, 26.2 mmol), and the mixture is stirred at the same temperature for 12 h. The reaction is quenched with H2O, and the mixture is partitioned between AcOEt and H2O. The organic phase is washed with saturated aqueous NaCl, dried (Na2SO4), filtered, and concentrated in vacuo. The residue (2) in CH2Cl2 (100 mL) is treated with 3-amino-1-propanol (2.0 mL, 26.2 mmol) at 0 °C and stirred at room temperature for 8 h. The resulting mixture is partitioned between AcOEt and H2O. The organic phase is washed with H2O (twice), saturated aqueous NaCl, dried (Na2SO4), filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography (40% AcOEt-hexane) to afford 3 as a colorless syrup (4.0 g, 84% over two steps).

References


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