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CAS RN: 109-63-7 | Product Number: B0527

Boron Trifluoride - Ethyl Ether Complex

Purity: >98.0%(W)
  • Boron Trifluoride - Diethyl Ether Complex
9   5   ≥20 
4   Contact Us ≥20 
15   4   ≥20 

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Both 100mL and 500mL bottles of this product are attached with a DualSeal (double cap).
For details, please refer to the page "DualSeal (Double Cap)".

Product Number B0527
Purity / Analysis Method >98.0%(W)
Molecular Formula / Molecular Weight BF__3·C__4H__1__0O = 141.93  
Physical State (20 deg.C) Liquid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Moisture Sensitive
Packaging and Container 100ML-DualSeal Bottle (View image),  500ML-DualSeal Bottle (View image)
CAS RN 109-63-7
Reaxys Registry Number 3909607
PubChem Substance ID 87563549
Merck Index (14) 1350
MDL Number


Appearance Colorless to Yellow to Orange clear liquid
Purity(Gravimetric) 98.0 to 102.0 %
Properties (reference)
Melting Point -60 °C
Boiling Point 124 °C
Specific Gravity (20/20) 1.13
Refractive Index 1.34
Solubility (soluble in) Ether,Alcohol
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 + H312 : Harmful if swallowed or in contact with skin.
H314 : Causes severe skin burns and eye damage.
H226 : Flammable liquid and vapor.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P240 : Ground/bond container and receiving equipment.
P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P233 : Keep container tightly closed.
P243 : Take precautionary measures against static discharge.
P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 : Use only non-sparking tools.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 : Wash contaminated clothing before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P403 + P235 : Store in a well-ventilated place. Keep cool.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number (DOT-AIR) UN2604
Class (DOT-AIR) 8/3
Packing Group (TCI-A) I
HS Number 3822.00.5095
t-Bu protection of Alcohols using Isobutylene



  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

Deprotection of BOM Groups using Benzenethiol and Boron Trifluoride



  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

BF3·Et2O Functioning as a Fluorine Source in an PhIO mediated Intermolecular Aminofluorination


Typical Procedure: To a solution of N-(but-3-en-1-yl)-4-methylbenzenesulfonamide (45 mg, 0.2 mmol) in CH2Cl2 (6 mL) in a flask are added BF3·Et2O (28.2 mg, 0.2 mmol) and PhIO (88 mg, 0.4 mmol). The reaction is stirred at room temperature for 4 h. The resulting mixture is diluted with ethyl acetate (50 mL). Then, the mixture is washed with sat. aqueous NaHCO3 (5 mL) and Na2S2O3 (5 mL). The separated aqueous phase is extracted with EtOAc (2×10 mL). The combined organic layer is washed with brine (10 mL), dried over MgSO4 and concentrated in vacuo to afford the crude product which is purified by flash column chromatography (Rf = 0.12, petroleum ether/EtOAc = 9/1) to give 3-fluoro-1-tosylpyrrolidine as a colorless solid (39 mg, 80% yield).


Stereoselective ring-opening hydrofluorination of aryl epoxides

Typical procedure: (RS,RS)-2-Methyl-3-phenyloxirane (4.5 g), BF3· OEt2 (1.38 mL) and CH2Cl2 (134 mL) were reacted at 20 °C for 5 min. Saturated aqueous NaHCO3 was then added and the mixture was stirred vigorously until both layers became clear. The layers were separated and the organic phase was washed with sat. aq. NaHCO3. The combined aqueous phases were extracted twice with CH2Cl2 and the combined organic extracts were dried and concentrated in vacuo. The residue was purified by flash column chromatography (gradient elution, 5 % to 40 % EtOAc in 30~40 °C petrol) gave (RS,RS)-1-fluoro-1-phenylpropane-2-ol as a colorless oil (4.31 g, 83 %, more than 99:1 dr).


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