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CAS RN: 485-49-4 | Product Number: B1890


Purity: >98.0%(T)(HPLC)
3   4   13  
1   1   18  

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Product Number B1890
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__0H__1__7NO__6 = 367.36  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
CAS RN 485-49-4
Reaxys Registry Number 98786
PubChem Substance ID 125308663
SDBS (AIST Spectral DB) 16661
Merck Index (14) 1203
MDL Number


Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 195.0 to 199.0 °C
Specific rotation [a]20/D +127.0 to +132.0 deg(C=1, CHCl3)
Properties (reference)
Melting Point 197 °C
Specific Rotation 132° (C=1,CHCl3)
Maximum Absorption Wavelength 325 nm
Solubility (soluble in) Benzene
Solubility (slightly sol. in) Chloroform
Solubility (very slightly) Alcohol,Ether
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
H401 : Toxic to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
Related Laws:
RTECS# LV0909840
Transport Information:
UN Number (DOT-AIR) UN1544
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2933.99.8210
Reagents convulsion or paralysis model


GABA Receptor Antagonist


GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nerve system and GABAA, GABAB, and GABAC receptors have been identified as the major receptors.1) GABAA and GABAC receptors are members of transmitter-gated ion channels, and GABAB receptors are the receptors that are coupled to G-protein and activate secondary messenger systems and Ca2+ and K+ ion channels.1)
Bicuculline (1) is a phthalide isoquinoline alkaloid isolated from a variety of plants, Dicentra, Corydalis, and Adlumia, genera of the Fumariaceae family. GABAA receptors are selectively blocked by 1.1-3) Affinity of 1 and the receptors have been studied by using mutational forms of recombinant receptor proteins.3) 1 and its quaternary salts also have actions other than as GABA-receptor antagonists including inhibition of cholinesterase, effects on 5-HT3, nicotinic, and N-methyl-D-aspartate (NMDA) receptors.2,3)


PubMed Literature

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