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CAS RN: 484-20-8 | Product Number: B2840

Bergapten


Purity: >98.0%(GC)
Synonyms:
  • 4-Methoxyfuro[3,2-g]benzopyran-7-one
  • 5-Methoxypsoralen
Documents:
1G
$167.00
2   7   ≥20 
5G
$603.00
7   1   6  

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Product Number B2840
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__1__2H__8O__4 = 216.19  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 484-20-8
Reaxys Registry Number 19560
PubChem Substance ID 87558737
Merck Index (14) 1157
Specifications
Appearance White to Light yellow powder to crystal
Purity(GC) min. 98.0 %
Melting point 189.0 to 193.0 °C
Properties (reference)
Melting Point 191 °C
Maximum Absorption Wavelength 480(MeOH) nm
Solubility in water Practically insoluble
Solubility (soluble in) Ether
Solubility (slightly sol. in) Benzene,Chloroform,Alcohol
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H317 : May cause an allergic skin reaction.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P363 : Wash contaminated clothing before reuse.
P405 : Store locked up.
Related Laws:
RTECS# LV1300000
Transport Information:
HS Number 2932.99.7000
Application
5-Methoxypsoralen (5-MOP): A Photosensitizer in Combination with UV-A irradiation, called PUVA

5-Methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP) [X0009] and 4,5',8-trimethylpsoralen [T2267] are naturally occurring linear psoralens (furocoumarins). They have been successfully used as photosensitizers in combination with UV-A irradiation which is called the psoralen-based PUVA (psoralen + UV-A) to manage dermatological diseases, such as psoriasis, vitiligo and cancer. Reportedly, the most important mechanism implies the [2 + 2] cycloaddition photoreaction of psoralen and a DNA pyrimidine nucleobase. The formation of psoralen-pyrimidine adducts prevents the division of the injured cells. In another photoreaction, the activated psoralen can transfer energy to molecular oxygen to generate reactive radicals or excited singlet oxygen which becomes prone to damage the membrane of the harmed cell. In addition, 5-MOP and 8-MOP work as Cytochrome P450 inhibitors. (The product is for research purpose only.)

References


PubMed Literature


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