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CAS RN: 667463-62-9 | Product Number: B4006

(2'Z,3'E)-6-Bromoindirubin-3'-oxime


Purity: >95.0%(HPLC)
Synonyms:
  • BIO
Documents:
5MG
$111.00
1   3   ≥20 
25MG
$384.00
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Product Number B4006
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__1__0BrN__3O__2 = 356.18  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 667463-62-9
Reaxys Registry Number 9653830
PubChem Substance ID 172089031
MDL Number

MFCD08705318

Specifications
Appearance Orange to Amber to Dark red powder to crystal
Purity(HPLC) min. 95.0 area%
Elemental analysis(Nitrogen) 11.30 to 12.30 %
Properties (reference)
Melting Point 300 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Related Laws:
RTECS# NM3241900
Transport Information:
HS Number 2933.99.8290
Application
Glycogen Synthase Kinase (GSK) Inhibitor
References

1)GSK-3-selective inhibitors derived from Tyrian purple indirubins

L. Meijer, A.-L. Skaltsounis, P. Magiatis, P. Polychronopoulos, M. Knockaert, M. Leost, X. P. Ryan, C. A. Vonica, A. Brivanlou, R. Dajani, C. Crovace, C. Tarricone, A. Musacchio, S. M. Roe, L. Pearl, P. Greengard, Chem. Biol. 2003, 10, 1255.

2)Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

P. Polychronopoulos, P. Magiatis, A.-L. Skaltsounis, V. Myrianthopoulos, E. Mikros, A. Tarricone, A. Musacchio, S. M. Roe, L. Pearl, M. Leost, P. Greengard, L. Meijer, J. Med. Chem. 2004, 47, 935.

3)Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

N. Sato, L. Meijer, L. Skaltsounis, P. Greengard, A. H. Brivanlou, Nat. Med. 2004, 10, 55.

4)The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes

A.-S. Tseng, F. B. Engel, M. T. Keating, Chem. Biol. 2006, 13, 957.


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