CAS RN: 667463-62-9 | Product Number: B4006
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|Purity / Analysis Method||>95.0%(HPLC)|
|Molecular Formula / Molecular Weight||C__1__6H__1__0BrN__3O__2 = 356.18|
|Physical State (20 deg.C)||Solid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Air Sensitive,Heat Sensitive|
|Reaxys Registry Number||9653830|
|PubChem Substance ID||172089031|
|Appearance||Orange to Amber to Dark red powder to crystal|
|Purity(HPLC)||min. 95.0 area%|
|Elemental analysis(Nitrogen)||11.30 to 12.30 %|
|Melting Point||300 °C|
|Hazard Statements||H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
|Precautionary Statements||P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
1)GSK-3-selective inhibitors derived from Tyrian purple indirubins
L. Meijer, A.-L. Skaltsounis, P. Magiatis, P. Polychronopoulos, M. Knockaert, M. Leost, X. P. Ryan, C. A. Vonica, A. Brivanlou, R. Dajani, C. Crovace, C. Tarricone, A. Musacchio, S. M. Roe, L. Pearl, P. Greengard, Chem. Biol. 2003, 10, 1255.
2)Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases
3)Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
4)The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes
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