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CAS RN: 179324-69-7 | Product Number: B5741

Bortezomib


Purity: >98.0%(HPLC)
Synonyms:
  • (R)-3-Methyl-1-[(S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido]butylboronic Acid
Documents:
10MG
$105.00
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50MG
$363.00
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Product Number B5741
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__9H__2__5BN__4O__4 = 384.24 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 179324-69-7
Reaxys Registry Number 8723817
PubChem Substance ID 468590677
Merck Index (14) 1351
MDL Number

MFCD09056737

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D -50.0 to -55.0 deg(C=1, MeOH)
Properties (reference)
Melting Point 123 °C
Solubility in water Soluble
Degree of solubility in water 76 mg/l  
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
Related Laws:
RTECS# ED7771666
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2933.99.7500
Application
Adeno-associated virus vector transduction enhancer

Bortezomib increases transduction by adeno-associated virus (AAV) vectors.1)

References


Application
Bortezomib: A Reversible Inhibitor of the 26S Proteasome in Mammalian Cells

Bortezomib (PS-341) is a reversible inhibitor of the 26S proteasome in mammalian cells. The proteasome is an abundant multi-enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells. The 26S proteasome is a large protein complex that degrades ubiquitinated proteins. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins. The orderly degradation of cellular proteins is critical for normal cell cycling and function, and inhibition of the ubiquitin-proteasome pathway with bortezomib results in cell-cycle arrest and apoptosis. (The product is for research purpose only.)

References


TCIMAIL
Documents (Note: Some products will not have analytical charts available.)
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