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CAS RN: 7689-03-4 | Product Number: C1495

(S)-(+)-Camptothecin


Purity: >97.0%(HPLC)
Synonyms:
Documents:
100MG
$61.00
5   8   16  
1G
$362.00
2   2   ≥20 

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Product Number C1495
Purity / Analysis Method >97.0%(HPLC)
Molecular Formula / Molecular Weight C__2__0H__1__6N__2O__4 = 348.36  
Physical State (20 deg.C) Solid
CAS RN 7689-03-4
Reaxys Registry Number 6075662
PubChem Substance ID 87566492
Merck Index (14) 1735
MDL Number

MFCD00081076

Specifications
Appearance White to Yellow to Green powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
Specific rotation [a]20/D +37.0 to +42.0 deg(C=0.4, CHCl3:MeOHl=8:2)
Properties (reference)
Specific Rotation 40° (C=0.4,CHCl3:MeOH=8:2)
Solubility in water Practically insoluble
Solubility (soluble in) Methanol,Chloroform
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# UQ0492000
Transport Information:
UN Number (DOT-AIR) UN1544
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2934.99.4400
Application
Camptothecin: The First Identified Topoisomerase-I Inhibitor

Camptothecin (CPT), a plant alkaloid with antitumor activity, was first isolated by Wall et al. in 1966 from the Chinese tree, Camptotheca acuminate. CPT shows strong anticancer activity against a wide range of experimental tumors, but also low water solubility and high toxicity (myelosuppression and hemorrhagic cystitis). Because of these disadvantages, various CPT derivatives have been discovered such as irinotecan hydrochloride [I0714] and topotecan. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death. (The product is for research purpose only.)

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