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CAS RN: 59729-32-7 | Product Number: C2370
Citalopram Hydrobromide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$91.00
|
4 | 1 | 27 |
|
| 5G |
$311.00
|
1 | 1 | 8 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | C2370 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__1FN__2O·HBr = 405.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 59729-32-7 |
| Related CAS RN | 59729-33-8 |
| Reaxys Registry Number | 5368282 |
| PubChem Substance ID | 125307911 |
| Merck Index (14) | 2318 |
| MDL Number | MFCD02101306 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 183 °C(dec.) |
GHS
Related Laws:
| RTECS# | NP6406750 |
Transport Information:
| HS Number | 2932.99.9090 |
Application
Citalopram Hydrobromide: A Selective Serotonin Reuptake Inhibitor (SSRI)
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). It is a racemic bicyclic phthalane derivative consisting of a 1:1 mixture of the R(-)- and S(+)[E0958] -enantiomers. The mechanism of action of citalopram HBr as an antidepressant is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT) [S0370]. In vitro and in vivo studies suggest that citalopram a highly SSRI with minimal effects on norepinephrine (NA) [A0906] and dopamine (DA) [A0305] neural reuptake. In additon, citalopram has no antagonistic activity towards DA, NA, 5-HT, histamine [H0146, H0147], GABA [A0282], acetylcholine [A0084, chloride], and morphine receptors. Although, the inhibition primarily due to the active S(+)-enantiomer, it is reported that the R(-)-enantiomer counteracts the activity of the S(+)[E0958] -enantiomer. (The product is for research purpose only.)
References
- Citalopram-pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity
- Citalopram (a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness)
- Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram
- Escitalopram versus citalopram: the surprising role of the R-enantiomer
- Determination of citalopram and escitalopram together with their active main metabolites desmethyl(es-)citalopram in human serum by column-switching high performance liquid chromatography (HPLC) and spectrophotometric detection
- Analytical procedures for the determination of the selective serotonin reuptake inhibitor antidepressant citalopram and its metabolites (a review)
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