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CAS RN: 59865-13-3 | Product Number: C2408

Cyclosporin A


Purity: >97.0%(HPLC)(N)
Synonyms:
  • Cyclosporin
Documents:
100MG
$62.00
5   5   ≥20 
1G
$368.00
1   Contact Us ≥20 

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Product Number C2408
Purity / Analysis Method >97.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__6__2H__1__1__1N__1__1O__1__2 = 1202.64  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 59865-13-3
Reaxys Registry Number 3647785
PubChem Substance ID 125307331
Merck Index (14) 2752
MDL Number

MFCD00274558

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(with Total Nitrogen) min. 97.0 %
Specific rotation [a]20/D -185 to -193 deg(C=0.5, MeOH)
Properties (reference)
Melting Point 151 °C
Specific Rotation -193° (C=0.5,MeOH)
Solubility (very soluble in) Ethanol,Methanol,Acetone,Ether
Solubility (soluble in) Chloroform
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dusts or mists.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws: / Compliance with laws, Regulations
RTECS# GZ4120000
Transport Information:
HS Number 2941.90.1050
Application
Cyclosporin A: A Calcineurin Inhibitor with Immunosuppressive Properties

Cyclosporin A (CsA) is a cyclic polypeptide immunosuppressant, and was initially isolated from the fungus Tolypocladium inflatum Gams in 1970. Cyclosporin A is practically insoluble in water, soluble in diethyl ether, and very soluble in methanol, ethanol and acetonitrile. Cyclosporin A inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that cyclosporin A is inactive by itself and requires binding to an intracellular protein, cyclophiline D (CypD), for activation in cells. A complex of CsA–CypD, calcium, calmodulin, and calcineurin (a calcium and calmodulin dependent protein phosphatase) is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent both T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus (FK506) [M2258] is also inhibits calcineurin and is more potent than cyclosporin A. Cyclosporin A is mainly metabolized by cytochrome P 450 IIIA (CYP3A) subfamilies. (The product is for research purpose only.)

References


PubMed Literature


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