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CAS RN: 93107-30-3 | Product Number: C2779
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid
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Purity: >98.0%(T)(HPLC)
Synonyms:
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$82.00
|
Contact Us | Contact Us | 8 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 289 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H412 : Harmful to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| HS Number | 2933.49.7000 |
Application
A Synthetic Intermediate of Fluoroquinolone Antibiotics
This product has been used as a synthetic intermediate of fluoroquinolone antibiotics, such as ciprofloxacin [C2510] [C2227 (hydrochloride)].
References
- Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids
- Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N -substituent in determining the structure-activity relationship
- Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids
- Synthesis and structure-activity relationships of 7-[3-(1-aminoalkyl)pyrrolidinyl]- and 7-[3-1-aminocycloalkyl)pyrrolidinyl]quinolone antibacterials
Application
Synthesis of Fluoroquinolone Antibacterials and Evaluations of their Antibacterial Activity
References
- Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids
- Quinolone antibacterial agents: Relationship between structure and in vitro inhibition of the human cytochrome P450 isoform CYP1A2
- U. Fuhr, G. Strobl, F. Manaut, E. M. Anders, F. Sörgel, E. Lopez-de-Brinas, D. T. Chu, A. G. Pernet, G. Mahr, F. Sanz, Mol. Pharmacol. 1993, 43, 191.
- Discovery of (3S)-Amino-(4R)-ethylpiperidinyl Quinolones as Potent Antibacterial Agents with a Broad Spectrum of Activity and Activity against Resistant Pathogens
- Microwave assisted amination of quinolone carboxylic acids: an expeditious synthesis of fluoroquinolone antibacterials
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