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CAS RN: 23593-75-1 | Product Number: C2867

Clotrimazole


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1-(2-Chlorotrityl)imidazole
  • 1-[(2-Chlorophenyl)diphenylmethyl]imidazole
Documents:
5G
$50.00
13   5   ≥20 
25G
$174.00
3   1   11  

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Product Number C2867
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__2H__1__7ClN__2 = 344.84  
Physical State (20 deg.C) Solid
CAS RN 23593-75-1
Reaxys Registry Number 622318
PubChem Substance ID 253661533
Merck Index (14) 2417
MDL Number

MFCD00057220

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 144.0 to 148.0 °C
Properties (reference)
Melting Point 147 °C
Maximum Absorption Wavelength 556(Phosphate buffer sol.) nm
Solubility in water Insoluble
Solubility (very soluble in) dichloromethane
Solubility (soluble in) Ethanol,Dimethylformamide,Methanol
Solubility (very slightly) Ether
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# NI4377000
Transport Information:
HS Number 2933.29.2000
Application
Clotrimazole: A Synthetic Imidazole Antifungal and an IKCA Inhibitor

Clotrimazole is a chemical synthetic imidazole antifungal. It has in vitro strong activity against Candida species, Trichophyton species, Microsporum species and Malassezia furfur. Besides that, clotrimazole has some in vitro activity against certain Gram-positive bacteria. Clotrimazole works to kill individual Candida or fungal cells by altering the permeability of the fungal cell wall. In additon, clotrimazole shows therapeutic effects on sickle cell disease, and etc. by inhibiting membrane intermediate-conductance Ca2+-activated K+ channels (IKCa). (The product is for research purpose only.)

References


PubMed Literature


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