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CAS RN: 1620086-77-2 | Product Number: C3326

5-Chlorosaligenyl-N,N-diisopropylphosphoramidite


Purity: >95.0%(T)
Synonyms:
  • 6-Chloro-N,N-diisopropyl-4H-benzo[d][1,3,2]dioxaphosphinin-2-amine
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200MG
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Product Number C3326
Purity / Analysis Method >95.0%(T)
Molecular Formula / Molecular Weight C__1__3H__1__9ClNO__2P = 287.72 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Moisture Sensitive,Heat Sensitive
CAS RN 1620086-77-2
Reaxys Registry Number 28732172
PubChem Substance ID 354334377
Specifications
Appearance White to Almost white powder to lump
Purity(Nonaqueous Titration) min. 95.0 %
Properties (reference)
Melting Point 45 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Related Laws:
Transport Information:
HS Number 2931.90.9052
Application
Solid-phase Synthesis of DNA and RNA 5'-O-Triphosphates

C3326

After oligonucleotide synthesis:

5-Chloro-saligenyl-N,N-diisopropylphosphoramidite (Reagent I, C3326) is coupled to the 5'-end of the DMT-off oligonucleotide. Oxidation of the formed 5'-phosphite using the same oxidizing reagent used in standard oligonucleotide synthesis leads to support-bonded 5'-cycloSal-oligonucleotides. Reaction with pyrophosphate (Reagent II, B5440) yields the corresponding 5'-triphosphates. The 5'-triphosphorylated oligonucleotides are obtained after cleavage from the support in high purity and excellent yields. The whole reaction sequence was adapted to be used on a standard oligonucleotide synthesizer.

References


PubMed Literature


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