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CAS RN: 1163-36-6 | Product Number: C3468
Clemizole Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)benzimidazole Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$206.00
|
Contact Us | 2 | 8 |
|
| 100MG |
$567.00
|
Contact Us | Contact Us | 13 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | C3468 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__0ClN__3·HCl = 362.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1163-36-6 |
| Related CAS RN | 442-52-4 |
| Reaxys Registry Number | 3791565 |
| PubChem Substance ID | 354335133 |
| Merck Index (14) | 2346 |
| MDL Number | MFCD00051435 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 11.00 to 12.00 % |
Properties (reference)
| Melting Point | 241 °C |
| Solubility in water | Soluble |
| Solubility (insoluble in) | Diethyl ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | DD6730000 |
Transport Information:
| HS Number | 2933.99.7900 |
Application
Clemizole Hydrochloride: A Histamine H1 Receptor Antagonist with Anti-Virus and Various Effects
Clemizole hydrochloride is a histamine H1 receptor antagonist1). Recently, it is reported that clemizole inhibits hepatitis C virus (HCV) replication2), and also potently inhibits transient receptor potential channel 5 (TRPC5).3) In addition, clemizole reportedly can be used for the treatment of Dravet syndrome which is often caused by Scn1a mutations, a voltage-gated sodium channel.4) (The product is for research purpose only.)
References
- 1)Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain
- 2)The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors
- 3)Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5
- 4)Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
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