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CAS RN: 35607-66-0 | Product Number: C3598

Cefoxitin


Purity: >98.0%(HPLC)
Synonyms:
  • (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
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Product Number C3598
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__1__7N__3O__7S__2 = 427.45 
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 35607-66-0
Reaxys Registry Number 4216947
PubChem Substance ID 468591185
Merck Index (14) 1936
MDL Number

MFCD00072014

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 95.0 %
Properties (reference)
Melting Point 127 °C(dec.)
Solubility in water Practically insoluble
Solubility (very soluble in) Acetone
Solubility (soluble in) Dimethylformamide
Solubility (insoluble in) Chloroform,Ether
GHS
Related Laws:
RTECS# XI0386500
Transport Information:
HS Number 2941.90.3000
Application
Cefoxitin: A Second Generation Cephem Antibiotic against beta-Lactamase

Cefoxitin and its sodium salt [C3602] are semi-synthetic antibiotic that are derived from cephamycin C which is produced by Streptomyces lactamdurans. Cefoxitins have bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including aerobes and anaerobes.1-3) Cefoxitins are second generation cephem antibiotics which act by inhibition bacterial cell wall synthesis. Due to the presence of a 7-α methoxy group in the β-lactam ring, cefoxitins exhibit a high degree of stability in the presence of beta-lactamases. In addition, cefoxitin disk diffusion method has been used for the tests for routine detection of all classes of MRSA.4,5)

References


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