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CAS RN: 2499715-43-2 | Product Number: C3902

CPO-PFP


Purity: >98.0%(HPLC)(qNMR)
Synonyms:
  • Perfluorophenyl 4-(3-Oxocycloprop-1-en-1-yl)butanoate
  • Pentafluorophenyl 4-(3-Oxo-1-cyclopropen-1-yl)butanoate
  • 3-Oxo-1-cyclopropene-1-butanoic Acid 2,3,4,5,6-Pentafluorophenyl Ester
Product Documents:
100MG
$168.00
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500MG
$505.00
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Product Number C3902
Purity / Analysis Method >98.0%(HPLC)(qNMR)
Molecular Formula / Molecular Weight C__1__3H__7F__5O__3 = 306.19 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Moisture Sensitive,Heat Sensitive
Packaging and Container 500MG-Glass Bottle with Plastic Insert (View image)
CAS RN 2499715-43-2
Reaxys Registry Number 41868973
Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(qNMR) min. 98.0 %
Melting point 64.0 to 68.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 66 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Related Laws:
Transport Information:
HS Number 2918.30.9000
Application
A Derivative of Cyclopropenone (CPO) to Precisely Modify the N-Terminal Cysteine Residue

Due to the active ester moiety, CPO-PFP is used as a cyclopropenone (CPO) incorporating reagent to react with primary amines. The cyclopropenone (CPO) moiety can precisely modify the N-terminal cysteine and does not react with non-N-terminal cysteine residues or other nucleophilic side chains. After the N-terminal modification of proteins with CPO, it is possible to introduce two different modifications on a single protein targeting the cysteine residues by treating internal cysteine residues with other cysteine modification reagents.

References


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