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CAS RN: 78628-80-5 | Product Number: D2049

Terbinafine Hydrochloride


Purity: >98.0%(T)(HPLC)
Synonyms:
  • trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride
  • (E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine Hydrochloride
Documents:
1G
$104.00
1   2   ≥20 
5G
$354.00
1   Contact Us ≥20 

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Product Number D2049
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__5N·HCl = 327.90  
Physical State (20 deg.C) Solid
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 78628-80-5
Related CAS RN 91161-71-6
Reaxys Registry Number 5660449
PubChem Substance ID 87568500
Merck Index (14) 9156
MDL Number

MFCD00145430

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Solubility in Methanol almost transparency
Properties (reference)
Melting Point 214 °C
GHS
Related Laws:
RTECS# QJ8600100
Transport Information:
HS Number 2921.45.9090
Application
Terbinafine Hydrochloride: A Potent Non-Competitive Inhibitor of Squalene Epoxidase

Terbinafine [T3677] and its hydrochloride, allylamine antifungals, are potent non-competitive inhibitors of fungal squalene epoxidase, a key enzyme in ergosterol biosynthesis. Ergosterol is an essential component of fungal cell membrane, and terbinafine inhibits ergosterol synthesis at the stage of squalene epoxidation. This results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiency. (The product is for research purpose only.)

References


PubMed Literature


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