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CAS RN: 1671-87-0 | Product Number: D3640
3,6-Di(2-pyridyl)-1,2,4,5-tetrazine

Purity: >98.0%(HPLC)
- 3,6-Bis(2-pyridyl)-1,2,4,5-tetrazine
Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
---|---|---|---|---|---|
1G |
$62.00
|
2 | 1 | 20 |
|
5G |
$310.00
|
1 | 5 | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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Product Number | D3640 |
Purity / Analysis Method | >98.0%(HPLC) |
Molecular Formula / Molecular Weight | C__1__2H__8N__6 = 236.24 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
CAS RN | 1671-87-0 |
Reaxys Registry Number | 405091 |
PubChem Substance ID | 87560390 |
MDL Number | MFCD00121717 |
Appearance | Red to Dark red to Brown powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Melting Point | 225 °C |
Pictogram |
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Signal Word | Warning |
Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
HS Number | 2933.39.9200 |
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Used Chemicals
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Procedure
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TCO-PEG3-biotin axial isomer (1) (5.9 mg, 0.01 mmol) was dissolved in 1:1 acetonitrile: water (1.4 mL) to prepare the 7.5 mmol/L solution (colorless). Next, 3,6-di(2-pyridyl)-1,2,4,5-tetrazine (2) (5.0 mg, 0.02 mmol) was dissolved in 1:1 solution of acetonitrile: water (1.4 mL) to prepare the 5.0 mmol/L solution (reddish-purple). 75 µL of each of the solutions were mixed together. During mixing, the reddish-purple color from 2 disappeared and the color of the solution became clear yellow, and UPLC-MS analysis confirmed the disappearance of 2 and the quantitative formation of the cycloaddition product 3.
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Experimenter’s Comments
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- The reaction mixture was monitored by UPLC-MS.
- As a preliminary step, UPLC-MS measurements of 1, 2, and blank were performed first.
- This reaction proceeded very rapidly, and the reddish-purple color from 2 disappeared immediately after mixing, changing to a clear yellow solution, and the reaction was completed.
- In this reaction, none of the new peaks except 3 were observed.
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Analytical Data
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Cycloaddition Compound 3
HRMS (ESI-TOF); m/z calced for C39H55N8O7S (M+H), 779.97; found 779.9.
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Lead Reference
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- Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels-Alder Reactivity
References
- Benzannulated Isobenzofurans
Articles/Brochures
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
Sample C of A
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Analytical Charts
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