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CAS RN: 23541-50-6 | Product Number: D4532

Daunorubicin Hydrochloride


Purity: >98.0%(N)
Synonyms:
  • Hydroxydaunorubicin Hydrochloride
Documents:
20MG
$220.00
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100MG
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Product Number D4532
Purity / Analysis Method >98.0%(N)
Molecular Formula / Molecular Weight C__2__7H__2__9NO__1__0·HCl = 563.98  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 23541-50-6
Related CAS RN 20830-81-3
Reaxys Registry Number 4229221
PubChem Substance ID 253661912
Merck Index (14) 2832
MDL Number

MFCD04974507

Specifications
Appearance Orange to Red powder to crystal
Purity(HPLC) min. 96.0 area%
Purity(with Total Nitrogen) min. 98.0 %(calcd.on dried substance)
Specific rotation [a]20/D +250 to +275 deg(C=0.15, MeOH)
Drying loss max. 7.5 %
Properties (reference)
Melting Point 167 °C(dec.)
Specific Rotation 260° (C=0.15,MeOH)
Maximum Absorption Wavelength 477(H2O) nm
Solubility in water Soluble
Solubility (soluble in) Methanol
Solubility (insoluble in) Ether,Chloroform,Benzene
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H317 : May cause an allergic skin reaction.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H351 : Suspected of causing cancer.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P285 : In case of inadequate ventilation wear respiratory protection.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P304 + P341 : IF INHALED: If breathing is difficult, remove person to fresh air and keep comfortable for breathing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P363 : Wash contaminated clothing before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# HB7878000
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2942.00.0500
Application
Daunorubicin Hydrochloride: An Anthracycline Antitumor Antibiotic

Daunorubicin Hydrochloride, an anthracycline antitumor antibiotic, was first isolated from fermentation broths of Streptomyces peucetius in 1967. Daunorubicin interacts with DNA by intercalation that causes disruption of transcription and replication. Daunorubicin also forms a complex with DNA and the enzyme topoisomerase II which is essential enzyme for DNA replication. The complexation hinders religation and leads to tumor cell apoptosis. Daunorubicin is mainly used for acute myeloid leukemia. (The product is for research purpose only.)

References


PubMed Literature


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