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CAS RN: 878143-33-0 | Product Number: D5481

Dolasetron Mesylate Monohydrate


Purity: >98.0%(HPLC)
Synonyms:
  • Dolasetron Methanesulfonate Monohydrate
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Product Number D5481
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__9H__2__0N__2O__3·CH__4O__3S·H__2O = 438.50 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 878143-33-0
Related CAS RN 115956-13-3
Reaxys Registry Number 8461425
PubChem Substance ID 468591363
Merck Index (14) 3411
MDL Number

MFCD01718979

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 6.10 to 6.70 %
Water 3.0 to 5.0 %
Properties (reference)
Melting Point 178 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# NL6015300
Transport Information:
HS Number 2933.39.4100
Application
Dolasetron Mesylate: A Selective Serotonin Subtype 3 (5-HT3) Receptor Antagonist

Dolasetron mesylate is a selective serotonin subtype 3 (5-HT3) receptor antagonist. It is rapidly converted in vivo to its active major metabolite, hydrodolasetron, which appears to be largely responsible for its pharmacological activity. 5-HT3 receptors are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, known as the emetic center of the brain. Therefore, selective 5-HT3 receptor antagonists, dolasetron, granisetron [G0401], ondansetron [O0407] and tropisetron [T2743] are used for the prevention of chemotherapy-induced nausea and vomiting, but they have been reported to be associated with QTc prolongation. (The product is for research purpose only.)

References


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