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CAS RN: 550-24-3 | Product Number: E1547
Embelin
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Purity: >95.0%(T)(HPLC)
Synonyms:
- Embelic Acid
- 2,5-Dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$327.00
|
Contact Us | Contact Us | 12 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | E1547 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__6O__4 = 294.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 550-24-3 |
| Reaxys Registry Number | 1885786 |
| MDL Number | MFCD00016369 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Melting point | 143.0 to 147.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 145 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DK4230000 |
Transport Information:
| HS Number | 2914.69.9000 |
Application
Embelin: A Non-Peptidic XIAP Inhibitor
Embelin is a plant-based benzoquinone that is the major active constituent of the fruits of Embelia ribes Burm, which has been used as a traditional medicinal plant since time immemorial. There are reports that embelin is a non-peptide inhibitor of XIAP (the X-linked inhibitor of apoptosis protein), an anti-apoptotic protein. Embelin acts as a modulator of the NF-κB, p53, PI3K/AKT, and STAT3 signaling pathways. It also exhibits potent cytotoxic, antioxidant and cancer chemopreventive effects. Therefore, embelin inhibits cell growth and induces apoptosis in cancer cells. (The product is for research purpose only.)
References
- Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database
- Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-κB (NF-κB) signaling pathway leading to suppression of NF-κB-regulated antiapoptotic and metastatic gene products
- Free radical scavenging reactions and antioxidant activity of embelin: Biochemical and pulse radiolytic studies
- Embelin – a drug of antiquity: shifting the paradigm towards modern medicine (a review)
- The application of embelin for cancer prevention and therapy (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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