text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 140681-55-6 | Product Number: F0358

N-Fluoro-N'-(chloromethyl)triethylenediamine Bis(tetrafluoroborate)

Purity: >95.0%(T)
  • 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate)
  • F-TEDA-BF4
Contact Us Contact Us ≥40 
Contact Us Contact Us ≥40 
Contact Us Contact Us ≥40 

* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Product Number F0358
Purity / Analysis Method >95.0%(T)
Molecular Formula / Molecular Weight C__7H__1__4B__2ClF__9N__2 = 354.26 
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 140681-55-6
Reaxys Registry Number 5368649
PubChem Substance ID 87570129
Merck Index (14) 8425
MDL Number


Appearance White to Light yellow powder to crystal
Purity(Iodometric Titration) min. 95.0 %
Properties (reference)
Melting Point 175 °C
Solubility in water Soluble
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H318 : Causes serious eye damage.
H317 : May cause an allergic skin reaction.
H412 : Harmful to aquatic life with long lasting effects.
H251 : Self-heating; may catch fire.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P235 + P410 : Keep cool. Protect from sunlight.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P363 : Wash contaminated clothing before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P407 : Maintain air gap between stacks/ pallets.
P420 : Store away from other materials.
Related Laws:
Transport Information:
UN Number (DOT-AIR) UN3088
Class (DOT-AIR) 4.2
Packing Group (TCI-A) II
HS Number 2933.99.9701
TCI Practical Example: Fluorination of 1,3-Dicarbonyl Compound Using F-TEDA-BF4


Used Chemicals


To a solution of acetoacetanilide (194 mg, 1.1 mmol) in acetonitrile and water (1:1, 4 mL) was added F-TEDA-BF4 (778 mg, 2.2 mmol). The reaction mixture was stirred at r.t. for 24 hours. Then solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate:hexane = 0:1 - 1:9 on silica gel) to give 2,2-difluoro-3-oxo-N-phenylbutanamide as a light yellow liquid (214 mg,y. 92%).

Experimenter’s Comments

The reaction mixture was monitored by LC.

Analytical Data


1H NMR (270 MHz, CDCl3); δ 7.97 (brs, 1H), 7.57-7.53 (m, 2H), 7.38 (t, 2H, J = 8.1 Hz), 7.25-7.18 (m, 1H), 6.60 (t, 1H, J = 73 Hz), 2.52 (t, 3H, J = 1.6 Hz).

Lead Reference

Metal-Free Fluorination of C(sp3)-H Bonds using a Catalytic N-Oxyl Radical


Typical Procedure: To a solution of 4-phenylbutyl benzoate (55.6 mg, 0.219 mmol) and NDHPI (1.36 mg, 0.00547 mmol) in MeCN (2.2 mL) is added F-TEDA-BF4 (155 mg, 0.438 mmol) at room temperature. The mixture is degassed by freeze-thaw for 3 times under Ar atmosphere, and stirred at 50 °C for 5 h. The reaction mixture is then neutralized with saturated aqueous NaHCO3, and extracted with EtOAc (3 mL×3). The combined organic layers are dried over Na2SO4, and concentrated. The residue is purified with flash column chromatography (silica gel, hexane : Et2O=30 : 1) to provide 4-benzoyloxy-1-phenylbutyl fluoride (43.1 mg, Y. 72%).


Regioselective Fluorohydroxylation Reaction of Arylallenes


Regiospecific fluorination of functionalized phenols

Typical procedue: To 4-(biphenyl)tributylstananne (44.3 mg) in acetone (2.0 mL) at 23°C is added silver triflate (51.4 mg) and N-fluoro-N'-(chloromethyl)triethylenediamine bis(tetrafluoroborate) (F-TEDA-BF4) (42.5 mg). The reaction mixture is stirred for 20 min at 23°C and then concentrated in vacuo. The residue is purified by preparative TLC eluting with hexane to give 12.0 mg of the fluorinated compound as colorless solid (70% yield).


PubMed Literature


Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.

The requested SDS is not available.

Please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Analytical Charts
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The requested analytical chart is not available. Sorry for the inconvenience.

Other Documents

Session Status
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page.

Your session has timed out. You will be redirected to the HOME page.