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CAS RN: 152121-47-6 | Product Number: F0864

SB 203580

Purity: >98.0%(HPLC)
  • 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
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Product Number F0864
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__1H__1__6FN__3OS = 377.44  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Heat Sensitive
CAS RN 152121-47-6
Reaxys Registry Number 7599740
MDL Number


Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 243.0 to 247.0 °C
Elemental analysis(Nitrogen) 10.60 to 11.60 %
Properties (reference)
Melting Point 245 °C
Related Laws:
RTECS# UT3967600
Transport Information:
HS Number 2933.39.6190
SB 203580: A Cell-Permeable and Specific p38 MAPK Inhibitor

Mitogen-activated protein kinase (MAPK) mediate signal transduction from cell surface receptors to the nucleus. p38 MAPK, a subtype of MAPK, is activated responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. SB 203580 is a cell-permeable p38 MAPK inhibitor that specifically blocks its kinase activity. Therefore, SB 203580 is widely used to elucidate the role of p38 MAPK in a wide array of biological systems.


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