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CAS RN: 623-33-6 | Product Number: G0102

Glycine Ethyl Ester Hydrochloride


Purity: >99.0%(T)
Synonyms:
  • H-Gly-OEt·HCl
Documents:
25G
$17.00
2   2   ≥20 
500G
$64.00
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Product Number G0102
Purity / Analysis Method >99.0%(T)
Molecular Formula / Molecular Weight C__4H__9NO__2·HCl = 139.58  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 623-33-6
Reaxys Registry Number 3594034
PubChem Substance ID 87570308
MDL Number

MFCD00012871

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(Argentometric Titration) min. 99.0 %
Solubility in Water almost transparency
Water max. 1.0 %
Glycine max. 0.6 %
Properties (reference)
Melting Point 146 °C
Solubility in water Completely soluble
Solubility (very soluble in) Ethanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Related Laws:
RTECS# MC0525000
Transport Information:
HS Number 2922.49.4950
Application
Preparation of Ethyl Diazoacetate

Typical Procedure: A solution containing 140 g glycine ethyl ester hydrochloride (1 mol) in 250 mL water is placed in a 2 L four neck flask. 600 mL dichloromethane is added and the mixture is cooled to -5 ℃ under a nitrogen atmosphere. A solution containing 83 g sodium nitrite in 250 mL water is cooled to 0 ℃ and added with stirring to the reaction mixture. While keeping the reaction temperature below -9 ℃, 95 g 5% sulfuric acid is added dropwise to the reaction over a 3 minute period. After ten minutes addition stirring the reaction is transferred to a 2 L separatory funnel while cold. The isolated yellow-greenish organic phase is poured into a cooled 1 L 5% sodium carbonate solution, then placed into a separatory funnel and shaken. The isolated aqueous phase is extracted with 75 mL dichloromethane, dried over 15 g anhydrous sodium sulfate, and concentrated under reduced pressure (350 mmHg). Further concentration at 20 mmHg and a bath temperature of 35 ℃ gives 90~100 g (79~88%) yellow oily substance. The product is pure enough to be used for ordinary synthesizing purposes. It is explosive, and distillation under even reduced pressure is hazardous. *Ethyl diazoacetate is explosive and very toxic. Wear protective gloves, protective goggles, protective mask, and use a safety screen. Work in a well ventilated fume hood.

References

  • Org. Synth. 1963, Coll. Vol. 4, 424.


PubMed Literature


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