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CAS RN: 133073-73-1 | Product Number: M1664

Methotrexate Hydrate


Purity: >98.0%(T)(HPLC)
Synonyms:
  • (+)-Amethopterin Hydrate
Documents:
1G
$171.00
1   1   ≥40 
5G
$624.00
1   Contact Us ≥40 

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Product Number M1664
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__0H__2__2N__8O__5·xH__2O = 454.45 (as Anhydrous)
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Hygroscopic
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 133073-73-1
Related CAS RN 59-05-2
Reaxys Registry Number 70669
PubChem Substance ID 87558856
Merck Index (14) 5985
MDL Number

MFCD00150847

Specifications
Appearance Light yellow to Brown powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +18.0 to +23.0 deg(C=0.1, 1mol/L NaOH sol.)(calcd.on anh.substance)
Water max. 10.0 %
Properties (reference)
Melting Point 205 °C(dec.)
Specific Rotation 21° (C=0.1,1mol/L NaOH sol.)
Solubility in water Insoluble
Solubility (insoluble in) Ether, Alcohol, Chloroform
GHS
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H372 : Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# MA1225000
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2933.99.7900
Application
Quorum sensing inhibitor

Reference


Application
Methotrexate: An Inhibitor of Dihydrofolate Reductase (DHFR)

Methotrexate (MTX), analog of folic acid, is an inhibitor of the enzyme dihydrofolate reductase (DHFR) which catalyzes the conversion of dihydrofolate to the active tetrahydrofolate, leading to interfere with folic acid metabolism. Result is inhibition of DNA synthesis and cell proliferation in S phases (the phase of DNA synthesis). Also, MTX has immunosuppressive and anti-inflammatory activity. Although no single mechanism is sufficient to account for all the anti-inflammatory activities of methotrexate, the release of adenosine from cells has been demonstrated. MTX is commonly used for the treatment of certain cancers including leukemia, rheumatoid arthritis, Crohn’s disease and psoriasis. (The product is for research purpose only.)

References


PubMed Literature


Documents (Note: Some products will not have analytical charts available.)
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