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CAS RN: 50-07-7 | Product Number: M2320

Ametycin


Purity: >98.0%(HPLC)
Synonyms:
  • Mitomycin C
Documents:
10MG
$125.00
6   11   ≥20 
50MG
$372.00
Contact Us 7   ≥20 

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Product Number M2320
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__5H__1__8N__4O__5 = 334.33  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 50-07-7
Reaxys Registry Number 3570056
PubChem Substance ID 172088986
Merck Index (14) 6215
MDL Number

MFCD00078109

Specifications
Appearance Dark red to Dark purple to Dark blue powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 16.4 to 17.0 %
Properties (reference)
Melting Point 64 °C
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# CN0700000
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) II
HS Number 2941.90.3000
Application
Ametycin: A DNA Interstrand Cross-Linking Agent

Ametycin (also known as Mitomycin C) is an antitumor antibiotic and a bifunctional alkylating agent, first isolated from the broth filtrate of Streptomyces caespitosus by Hata et al. (Kitasato Institute) in 1955. Some metabolic activation forms of ametycin inhibit DNA synthesis by causing cross-linking specificity for the sequence CpG. Ametycin causes cell cycle arrest in phase-nonspecific but is most active in S and G phases, and induces apoptosis in cancer cells.

References


PubMed Literature


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