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CAS RN: 749886-87-1 | Product Number: M2734

4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine


Purity: >98.0%(GC)
Synonyms:
  • JSH-23
Documents:
100MG
$464.00
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Product Number M2734
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__1__6H__2__0N__2 = 240.35 
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 749886-87-1
Reaxys Registry Number 24398255
PubChem Substance ID 253661372
MDL Number

MFCD09753595

Specifications
Appearance White to Light yellow to Light orange powder to crystal
Purity(GC) min. 98.0 %
Melting point 101.0 to 105.0 °C
Properties (reference)
Melting Point 103 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Related Laws:
Transport Information:
HS Number 2921.59.8090
Application
核内因子κB (NFκB) 活性化阻害剤

This compound, often called as JSH-23, is an inhibitor of nuclear factor-κB (NFκB) transcriptional activity (IC50= 7.1 µM). NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. JSH-23 has been reported to inhibit lipopolysaccharide(LPS)-induced nuclear translocation of NFκB without affecting the process of NFκB - IκB complex degradation.

References


PubMed Literature


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