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CAS RN: 70476-82-3 | Product Number: M3110
Mitoxantrone Dihydrochloride
×
Purity: >97.0%(HPLC)
Synonyms:
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone Dihydrochloride
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthracene-9,10-dione Dihydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 25MG |
$34.00
|
1 | 1 | 38 |
|
|
| 100MG |
$91.00
|
Ships from Portland the same day* | 1 | ≥40 |
|
* Items in stock locally typically ship the same day of ordering. Items from Japan stock are able to ship from a US warehouse within 2 weeks after ordering. For additional estimated shipment times, please refer to the Shipping Simulation tool. Note: Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M3110 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__8N__4O__6·2HCl = 517.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 70476-82-3 |
| Related CAS RN
|
65271-80-9 |
| Reaxys Registry Number | 4835931 |
| PubChem Substance ID | 468592271 |
| Merck Index (14) | 6217 |
| MDL Number | MFCD00242943 |
Specifications
| Appearance | Dark green to Dark purple to Black powder to crystal |
| Purity(Argentometric Titration) | min. 95.0 % |
| Purity(HPLC) | min. 97.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 267 °C(dec.) |
| Maximum Absorption Wavelength | 660 nm (H__2O) |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Acetone, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H310 : Fatal in contact with skin. H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P307 + P311 : IF exposed: Call a POISON CENTER or doctor/ physician. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P350 + P310 : IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/ physician. P405 : Store locked up. |
Related Laws:
| RTECS# | CB0386900 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | II |
| HS Number | 2922.50.2500 |
Application
Virus research
References
- Mitoxantrone modulates a heparan sulfate‑spike complex to inhibit SARS‑CoV‑2 infection
- Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone
- Developing a Dynamic Pharmacophore Model for HIV-1 Integrase
- Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells
- Experimental antitumor activity of aminoanthraquinones
- Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
- Mechanism of Action of Topoisomerase II-Targeted Antineoplastic Drugs
- Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer
- Mechanism of action of mitoxantrone (a review)
- HPLC analysis of mitoxantrone in mouse plasma and tissues: Application in a pharmacokinetic study
- Mitoxantrone hydrochloride (a review on the description, synthesis, physical properties, stability, pharmacology, and detection)
Application
Mitochondria research
Reference
Application
Mitoxantrone Dihydrochloride: A Synthetic Anthracycline Antitumor Agent with Improved Tolerability
Mitoxantrone [M3133] and its dihydrochloride are synthetic anthracycline antitumor agents that are structurally similar to doxorubicin hydrochloride [D4193] and daunorubicin hydrochloride [D4532]. Mitoxantrones intercalate into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. .Mitoxantrones also inhibit DNA repair by inhibiting topoisomerase II which results in fragmentation of DNA. Mitoxantrones display an improved tolerability profile compared with doxorubicin and other anthracyclines, but cross-resistance with the anthracyclines has been demonstrated. (The product is for research purpose only.)
References
Documents
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