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CAS RN: 54-11-5 | Product Number: N0079

Nicotine


Purity: >95.0%(GC)(T)
Synonyms:
  • (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
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25ML
$58.00
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100ML
$175.00
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500ML
$525.00
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Product Number N0079
Purity / Analysis Method >95.0%(GC)(T)
Molecular Formula / Molecular Weight C__1__0H__1__4N__2 = 162.24  
Physical State (20 deg.C) Liquid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Hygroscopic
CAS RN 54-11-5
Reaxys Registry Number 82109
PubChem Substance ID 87573472
SDBS (AIST Spectral DB) 6729
Merck Index (14) 6524
MDL Number

MFCD00006369

Specifications
Appearance Colorless to Red to Green clear liquid
Purity(GC) min. 95.0 %
Purity(Nonaqueous Titration) min. 95.0 %
Specific rotation [a]20/D -160 to -173 deg(C=10, Acetone)
Properties (reference)
Melting Point -80 °C
Boiling Point 91 °C/3 mmHg
Flash point 95 °C
Specific Gravity (20/20) 1.02
Specific Rotation -167° (C=10,Acetone)
Refractive Index 1.53
Solubility in water Completely miscible
Solubility (very soluble in) Alcohol,Chloroform,Ether
GHS
Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H361 : Suspected of damaging fertility or the unborn child.
H370 : Causes damage to organs.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P262 : Do not get in eyes, on skin, or on clothing.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P284 : Wear respiratory protection.
P391 : Collect spillage.
P307 + P311 : IF exposed: Call a POISON CENTER or doctor/ physician.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P350 + P310 : IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/ physician.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
Related Laws:
RTECS# QS5250000
Transport Information:
UN Number (DOT-AIR) UN1654
Class (DOT-AIR) 6.1
Packing Group (TCI-A) II
HS Number 2933.39.9100
Application
Nicotine: A Nicotinic Acetylcholine Receptors (nAChRs) Agonist

Nicotine (or (-)-(S)-nicotine) is an alkaloid and natural insecticide that acts as an anti-herbivore chemical in tobacco plants. Nicotine acts as a nicotinic acetylcholine receptors (nAChRs) agonist. nAChRs are a family of ligand-gated ion channels. Recent studies have shown that nicotine activates neuronal nAChRs in peripheral and central nervous systems leading to depolarization of cell membranes and elevation of intracellular calcium levels, which are considered to cause stimulation of neurotransmitter release, synaptic transmission, intracellular signal transduction and gene expression.1) Nicotine is also used as a probe agent for phenotyping cytochrome P450 2A6 (CYP2A6) which is involved in the metabolism of nicotine.2) (The product is for research purpose only.)

References


PubMed Literature


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