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CAS RN: 100-02-7 | Product Number: N0220

4-Nitrophenol


Purity: >99.0%(GC)
Synonyms:
Documents:
25G
$22.00
17   5   ≥20 
100G
$45.00
1   2   17  
500G
$121.00
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Product Number N0220
Purity / Analysis Method >99.0%(GC)
Molecular Formula / Molecular Weight C__6H__5NO__3 = 139.11  
Physical State (20 deg.C) Solid
CAS RN 100-02-7
Reaxys Registry Number 1281877
PubChem Substance ID 87573588
SDBS (AIST Spectral DB) 2681
Merck Index (14) 6620
MDL Number

MFCD00007331

Specifications
Appearance White to Light yellow to Green powder to crystal
Purity(GC) min. 99.0 %
Melting point 112.0 to 116.0 °C
Solubility in EtOH almost transparency
Transition interval(pH) (very pale yellow)4.8 to 7.6(yellow)
Properties (reference)
Melting Point 114 °C
Boiling Point 279 °C
Solubility in water Slightly soluble
Degree of solubility in water 12.4 g/l   20 °C
Solubility (soluble in) Ether,Alcohol
GHS
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H312 + H332 : Harmful in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H373 : May cause damage to organs through prolonged or repeated exposure.
H317 : May cause an allergic skin reaction.
H401 : Toxic to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P307 + P311 : IF exposed: Call a POISON CENTER or doctor/ physician.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P405 : Store locked up.
Related Laws:
RTECS# SM2275000
Transport Information:
UN Number (DOT-AIR) UN1663
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2908.99.2000
Application
Condensing Agent

Experimental procedure: Boc-Gly-OH (1.98 kg, 11.3 mol) and 4-nitrophenol (1.73 kg, 12.43 mol, 1.1 eq.) are dissolved in dry dioxane (25 L), a solution of DCC (2.8 kg, 13.56 mol, 1.2 eq.) in dry dioxane (10 L) is added and the mixture is stirred for 8-10 h. After cooling for 2 h, the precipitate is removed and the filtrate is used directly for next reaction without purification. The mixture of glycine (0.94 kg, 12.43 mol, 1.1 eq.) and NaHCO3 (1.05 kg, 12.43 mol, 1.1 eq.) in H2O (10 L) is slowly added to the solution of Boc-Gly-ONp in dioxane (25 L). The solution is stirred at about 25 °C for 7 h and then evaporated under reduced pressure. The residue is acidified to a pH 2-3 with 10% citric acid and extracted with EtOAc (3 × 20 L). The organic phase is successively washed with brine (20 L), dried, and evaporated to give Boc-Gly-Gly-OH (2.37 kg, 90%) as a white crystal.

References


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