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CAS RN: 114-80-7 | Product Number: N0358
Neostigmine Bromide
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Purity: >99.0%(T)
Synonyms:
- (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide
- (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$90.00
|
8 | 1 | 3 |
|
| 25G |
$294.00
|
4 | 1 | 15 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | N0358 |
| Purity / Analysis Method | >99.0%(T) |
| Molecular Formula / Molecular Weight | C__1__2H__1__9BrN__2O__2 = 303.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 114-80-7 |
| Related CAS RN | 59-99-4 |
| Reaxys Registry Number | 3640678 |
| PubChem Substance ID | 87573710 |
| SDBS (AIST Spectral DB) | 5015 |
| Merck Index (14) | 6464 |
| MDL Number | MFCD00011795 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 99.0 %(after drying) |
| Solubility in Water | almost transparency |
| Drying loss | max. 1.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility (soluble in) | Alcohol, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | BR3150000 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2924.29.9500 |
Application
競合的な抗コリンエステラーゼ阻害剤，ネオスチグミンブロミド
Neostigmine bromide, a synthetic physostigmine analog, is a competitive cholinesterase inhibitor. Unlike the plant alkaloid physostigmine [P0406], neostigmine bromide has a quaternary nitrogen, hence it more polar and does not cross the blood-brain barrier. Neostigmine bromide induces an increase in acetylcholine (ACh) in the synaptic cleft through reversible inhibition of its hydrolysis by acetylcholinesterase (AChE), and activates peripheral cholinergic nervous system. Neostigmine bromide used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as tubocurarine [C0433]. (The product is for research purpose only.)
References
- The direct action of prostigmine on skeletal muscle; its relationship to the choline esters
- Acetylcholinesterase inhibitors: a patent review (2008 - present)
- LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood
- Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine
PubMed Literature
Product Articles
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Safety Data Sheet (SDS)
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Specifications
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