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CAS RN: 2207-75-2 | Product Number: O0164

Potassium Oxonate


Purity: >98.0%(T)(HPLC)
Synonyms:
  • Allantoxanic Acid Potassium Salt
  • Oxonic Acid Potassium Salt
  • Potassium Allantoxanate
  • Potassium 4,6-Dihydroxy-1,3,5-triazine-2-carboxylate
Documents:
5G
$29.00
2   Contact Us ≥20 
25G
$93.00
Contact Us 2   ≥20 

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Product Number O0164
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__4H__2KN__3O__4 = 195.18  
Physical State (20 deg.C) Solid
CAS RN 2207-75-2
Related CAS RN 937-13-3
Reaxys Registry Number 4049961
PubChem Substance ID 87574167
MDL Number

MFCD00010565

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 300 °C
GHS
Related Laws:
RTECS# RR4580000
Transport Information:
HS Number 2933.69.6050
Application
Potassium Oxonate: An Inhibitor of Orotate Phosphoribosyltransferase (OPRT)

Potassium oxonate is an inhibitor of orotate phosphoribosyltransferase (OPRT) that is an enzyme involved in the biosynthesis of pyrimidine nucleotides and catalyzes the phosphorylation of 5-FU [F0151] to an active metabolite 5-fluorouridine-5'-monophosphate (FUMP). The gastrointestinal toxicity (GIT) of the oral administration of 5-FU is also caused by the phosphorylation by OPRT in the gut wall. Potassium oxonate selectively and competitively inhibits OPRT. As a result, 5-FU associated gastrointestinal toxic effects are reduced. Potassium oxonate is often used as combined agents to enhance the antitumor activity of fluoropyrimidines, such as S-1 (tegafur [F0635] a prodrug of 5-FU, gimeracil [C2243] and potassium oxonate at a molar ratio of 1:0.4:1). (The product is for research purpose only.)

References


Application
Reagent for hyperuricemia (gout) model

References


PubMed Literature


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