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CAS RN: 28957-04-2 | Product Number: O0387

Oridonine


Purity: >98.0%(HPLC)
Synonyms:
  • (14R)-7α,20-Epoxy-1α,6β,7,14-tetrahydroxykaur-16-en-15-one
  • (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
Documents:
50MG
$137.00
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Product Number O0387
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__0H__2__8O__6 = 364.44 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 28957-04-2
Reaxys Registry Number 1691227
PubChem Substance ID 468592517
MDL Number

MFCD00221762

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation -57.0 to -61.0 deg (C=0.1, ethanol)
NMR confirm to structure
Properties (reference)
Melting Point 252 °C
Maximum Absorption Wavelength 237(EtOH) nm
GHS
Related Laws:
RTECS# NZ8177000
Transport Information:
HS Number 2932.99.9090
Application
Oridonin: An Active Diterpene with NLRP3 Inhibitory Activity

Oridonin (or oridonine) is an active diterpene isolated from Rabdosia rubescens used as a traditional Chinese medicine. Oridonin has been reported to possess a broad range of biological activities including anti-inflammation, anti-bacterial, anti-neoplastic and neuroprotective effects. It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. Oridonin has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity. (The product is for research purpose only.)

References

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