CAS RN: 24367-66-6 | Product Number: O0533
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
|Purity / Analysis Method||>95.0%(T)|
|Molecular Formula / Molecular Weight||C__5H__4NNaO__2S = 165.14|
|Physical State (20 deg.C)||Solid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Hygroscopic|
|Reaxys Registry Number||5659853|
|Appearance||White to Light yellow powder to crystal|
|Purity(HPLC)||min. 93.0 area%|
|Purity(Nonaqueous Titration)||min. 95.0 %|
|Melting point||283.0 to 287.0 °C|
|Melting Point||285 °C|
|Solubility in water||Soluble|
|Hazard Statements||H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
|Precautionary Statements||P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Sodium pyridine-2-sulfinate (0.15 g，0.88 mmol), palladium(II) acetate (6.6 mg, 29 µmol), di-tert-butyl(methyl)phosphonium tetrafluoroborate (15 mg, 58 µmol), 4-bromotoluene (0.10 g, 0.58 mmol), potassium carbonate (0.16 g, 1.2 mmol), 1,4-dioxane (3 mL) were placed in a pressure vessel under nitrogen atmosphere at room temperature. The reaction mixture was stirred for 4 days at 120 °C, then palladium(II) acetate (6.6 mg, 29 µmol) and di-tert-butyl(methyl)phosphonium tetrafluoroborate (15 mg, 58 µmol) was added. The reaction mixture was stirred for another 4 days at 120 °C, then diluted with ethyl acetate and washed with water. The organic layer was dried by sodium sulfate, then concentrated under reduced pressure. The resulting crude product was purified by column chromatography (hexane:ethyl acetate = 5:1 on silica gel) to give 1 as a yellow oil (29 mg, 29% yield).
The reaction mixtures were monitored by 1H NMR.
1H NMR (400 MHz, CDCl3); δ 8.68 (d, 1H, J = 5.0 Hz), 7.89 (d, 2H, J = 8.3 Hz), 7.78-7.68 (m, 2H), 7.28 (d, 2H, J = 7.8 Hz), 7.23-7.18 (m, 1H), 2.41 (s, 3H).
13C NMR (101 MHz, CDCl3); δ 157.8, 149.7, 139.1, 136.8, 136.7, 129.6, 126.9, 121.9, 120.4, 21.4. (2C are overlapped at aromatic area)
- Catalyst Selection Facilitates the Use of Heterocyclic Sulfinates as General Nucleophilic Coupling Partners in Palladium-Catalyzed Coupling Reactions
Safety Data Sheet (SDS)
The requested SDS is not available.
Please Contact Us for more information.
C of A & Other Certificates
The requested analytical chart is not available. Sorry for the inconvenience.