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CAS RN: 95-54-5 | Product Number: P0168

1,2-Phenylenediamine


Purity: >98.0%(GC)(T)
Synonyms:
  • 1,2-Diaminobenzene
Documents:
25G
$22.00
2   2   ≥100 
100G
$47.00
14   2   ≥100 
500G
$132.00
2   1   ≥80 

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Product Number P0168
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__6H__8N__2 = 108.14 
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive
CAS RN 95-54-5
Reaxys Registry Number 606074
PubChem Substance ID 87574418
SDBS (AIST Spectral DB) 2795
Merck Index (14) 7284
Colour Index 76010
MDL Number

MFCD00007721

Specifications
Appearance White to Light yellow to Dark green powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 100.0 to 105.0 °C
Properties (reference)
Melting Point 103 °C
Boiling Point 265 °C
Solubility in water Soluble
Degree of solubility in water 41 g/l   35 °C
Solubility (soluble in) Benzene, Acetone
GHS
Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H330 : Fatal if inhaled.
H302 + H312 : Harmful if swallowed or in contact with skin.
H319 : Causes serious eye irritation.
H371 : May cause damage to organs.
H370 : Causes damage to organs.
H373 : May cause damage to organs through prolonged or repeated exposure.
H317 : May cause an allergic skin reaction.
H341 : Suspected of causing genetic defects.
H351 : Suspected of causing cancer.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P284 : Wear respiratory protection.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P391 : Collect spillage.
P307 + P311 : IF exposed: Call a POISON CENTER or doctor/ physician.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P363 : Wash contaminated clothing before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
Related Laws:
RTECS# SS7875000
Transport Information:
UN Number (DOT-AIR) UN1673
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2921.51.1000
Application
One-pot Synthesis of Benzodiazepin Derivatives via Three-component Reaction

P0168

Reference


Application
Synthesis of Benzimidazole Using Gold’s Reagent

A dry, three-necked, round-bottomed flask is equipped with a condenser, thermometer, magnetic stirrer and is placed under a nitrogen atmosphere. Into the flask is placed 100 mL of dry 1,4-dioxane along with 5.4 g (0.05 mol) of 1,2-phenylenediamine and 9.9 g (0.061 mol) of Gold’s reagent. The mixture is refluxed overnight, cooled to room temperature and 4.1 g (0.05 mol) of anhydrous sodium acetate and 2 mL of glacial acetic acid are added. The resulting mixture is refluxed for 3 hours, cooled to room temperature and the solvent is removed in vacuo. The residue is taken up in chloroform (100 mL), extracted with a saturated, aqueous solution of sodium bicarbonate (3 x 50 mL) and dried over anhydrous magnesium sulfate. After removing the drying agent by filtration, the chloroform extract is concentrated in vacuo to leave a solid which is collected by vacuum filtration with the aid of a small amount (15 mL) of water. The resulting benzimidazole amounts to 3.7 g (63% yield).

References


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