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CAS RN: 24057-28-1 | Product Number: P0942
Pyridinium p-Toluenesulfonate
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Purity: >98.0%(T)
Synonyms:
- PPTS
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25G |
$17.00
|
5 | 3 | ≥80 |
|
| 100G |
$50.00
|
3 | 3 | 30 |
|
| 500G |
$171.00
|
Contact Us | Contact Us | ≥60 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | P0942 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__5H__5N·C__7H__8O__3S = 251.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 24057-28-1 |
| Reaxys Registry Number | 3764305 |
| PubChem Substance ID | 87575059 |
| MDL Number | MFCD00013108 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 118.0 to 122.0 °C |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 120 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Ethanol, Chloroform, dichloromethane, Acetone |
GHS
| Signal Word | Warning |
| Hazard Statements | H320 : Causes eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Related Laws:
Transport Information:
| HS Number | 2933.39.9200 |
Application
Application for Introduction of Protecting Groups Using PPTS as an Acid Catalyst
Typical procedure :PPTS catalyzed THP protection of (R)-(+)-glycidol
Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
References
- A Facile Synthesis of (S)-Felodipine
Application
PPTS Catalyzed Hydrolysis of Dioxolane-type Acetals
Reference
- Pyridinium Tosylate, A Mild Catalyst for Formation and Cleavage of Dioxolane-type Acetals
PubMed Literature
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