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CAS RN: 33069-62-4 | Product Number: P1632

Paclitaxel


Purity: >98.0%(HPLC)
Synonyms:
Documents:
100MG
$320.00
12   4   19  

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Product Number P1632
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__4__7H__5__1NO__1__4 = 853.92  
Physical State (20 deg.C) Solid
CAS RN 33069-62-4
Reaxys Registry Number 1420457
PubChem Substance ID 87558555
Merck Index (14) 6982
Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Specific rotation -49.0 to -54.0 deg(C=1, MeOH)
Properties (reference)
Melting Point 211 °C(dec.)
Specific Rotation -52° (C=1,MeOH)
Maximum Absorption Wavelength 227(MeOH) nm
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H361 : Suspected of damaging fertility or the unborn child.
H317 : May cause an allergic skin reaction.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H341 : Suspected of causing genetic defects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P285 : In case of inadequate ventilation wear respiratory protection.
P201 : Obtain special instructions before use.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P405 : Store locked up.
Related Laws:
RTECS# DA8340700
Transport Information:
HS Number 2914.50.3000
Application
Paclitaxel: An Antimicrotubule Agent

Paclitaxel is an antimicrotubule agent. It was initially extracted from the bark of Taxus brevifolia, and at present, it is semi-synthesized from 10-deacetylbaccatin III [D4148] isolated from the yew tree (Genera Taxus). The tubulin has two subunits, α and β, which are arranged in a cylindrical pattern to form a hollow protein. Paclitaxel specifically binds to the β-tubulin subunit of microtubules, promotes and stabilizes microtubule polymerization. As the result, it influences the formation and function of spindles (made up of microtubules) during mitosis (M phase), and also affects the function of microtubules in the cell. It is thought to be cytotoxic by arresting the cell cycle during M phase. For your reference, [B4127] and [H1656] are synthetic Intermediates of the side chains of docetaxel [D4102] and paclitaxel. (The product is for research purpose only.)

References


Application
Reagent for pain model

References

  • A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
    • R. C. Polomano, A. J. Mannes, U. S. Clark, G. J. Bennett, Pain 2001, 94, 293.
  • Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy


Application
Reviews on Formulations and Drug Delivery Systems (DDS) of Paclitaxel

References


PubMed Literature


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