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CAS RN: 59-33-6 | Product Number: P2369
Pyrilamine Maleate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Mepyramine Maleate
- N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$35.00
|
1 | 1 | 30 |
|
| 25G |
$102.00
|
1 | 2 | 4 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P2369 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__3N__3O·C__4H__4O__4 = 401.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 59-33-6 |
| Related CAS RN
|
91-84-9 |
| Reaxys Registry Number | 3836479 |
| PubChem Substance ID | 354333684 |
| Merck Index (14) | 7984 |
| MDL Number | MFCD00069333 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 100.0 to 104.0 °C |
Properties (reference)
| Melting Point | 102 °C |
| Maximum Absorption Wavelength | 310 nm (EtOH) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UT1225000 |
Transport Information:
| HS Number | 2933.39.4100 |
Application
Pyrilamine Maleate: A First Generation Histamine H1 Receptor Antagonist
Pyrilamine maleate, also known as pyrilamine maleate, is a first generation histamine H1 receptor antagonist. Pyrilamine binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Pyrilamine permeates the blood-brain barrier causing drowsiness. Pyrilamine also has anticholinergic properties. For reference, we also have related first generation histamine H1 receptor antagonists, such as pheniramine maleate [P2271], chlorpheniramine maleate [C0873] and bromopheniramine maleate [B5167]. (The product is for research purpose only.)
References
- Physical and biological properties of pyrilamine (a review)
- Histaminergic systems and sleep. Studies in man with H1 and H2 antagonists
- Influence of certain H1-blockers on the step-through active avoidance response in rats
- Mepyramine, a Histamine H1 Receptor Inverse Agonist, Binds Preferentially to a G Protein-coupled Form of the Receptor and Sequesters G Protein
- Delineation of receptor-ligand interactions at the human histamine H1 receptor by a combined approach of site- directed mutagenesis and computational techniques - or - how to bind the H1 receptor (a review)
- Simultaneous determination of pseudoephedrine, pheniramine, guaifenesin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography
PubMed Literature
Product Articles
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Safety Data Sheet (SDS)
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Specifications
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