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CAS RN: 878376-35-3 | Product Number: P2398
Pyridine-2-sulfonyl Fluoride
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Purity: >98.0%(GC)(T)
Synonyms:
- PyFluor
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$234.00
|
1 | 4 | ≥40 |
|
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| Product Number | P2398 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__5H__4FNO__2S = 161.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 878376-35-3 |
| Reaxys Registry Number | 10151877 |
| PubChem Substance ID | 354333991 |
| MDL Number | MFCD09265513 |
Specifications
| Appearance | White to Almost white powder to lump |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 26 °C |
| Flash point | 96 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H290 : May be corrosive to metals. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dusts or mists. P234 : Keep only in original container. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P390 : Absorb spillage to prevent material damage. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P406 : Store in corrosive resistant container with a resistant inner liner. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number (DOT-AIR) | UN3261 |
| Class (DOT-AIR) | 8 |
| Packing Group (TCI-A) | II |
| HS Number | 2933.39.9200 |
Application
TCI Practical Example: Fluorination of an Alcohol Using PyFluor
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Used Chemicals
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Procedure
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A solution of PyFluor (513 mg, 3.19 mmol) in dry toluene (3.6 mL) was added to a solution of 2,3-O-isopropylidene-D-ribonic γ-lactone (500 mg, 2.66 mmol) and DBU (0.79 mL, 5.31 mmol) in toluene (3.0 mL) at 0 °C, and the solution was stirred at room temperature for one day. The reaction mixture was quenched with water (10 mL) and the aqueous layer was extracted with ethyl acetate (3 x 5 mL). The combined organic layer was washed with sat. NH4Cl aq. and brine, dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate:hexane = 0:100 - 15:85 on silica gel) to give the fluorinated compound 1 as a white solid (309 mg, 61% yield.).
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:2, Rf = 0.33).
It was easy to weigh PyFluor after melting PyFluor by heating with hot water bath because the melting point is 26 °C.
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Analytical Data
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Fluorinated Compound 1
1H NMR (270 MHz, DMSO-d6); δ 4.94-4.74 (m, 4H), 4.64 (ddd, J = 3.0, 10.8, 27.8 Hz, 1H), 1.37 (s, 3H), 1.33 (s, 3H).
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Lead Reference
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- PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent
Application
PyFluor: A Stable Deoxyfluorinating Agent
Experimental procedure: A vial is charged sequentially with substrate (1.0 mmol), toluene (1 mL, 1.0 mol/L), PyFluor (177 mg, 1.1 eq.), and DBU (300 µL, 2 eq.). PyFluor is dispensed as a liquid (m.p. 23 – 26 °C). The mixture is stirred at room temperature for 48 hours under ambient atmosphere. Occasionally, an exotherm is observed following addition of base, corresponding to sulfonate ester formation. Reaction progress is accompanied by formation of pale yellow to dark orange precipitates. Products are isolated by column chromatography.
References
- PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent
PubMed Literature
Articles/Brochures
TCIMAIL
[TCI Practical Example] Deoxygenative Fluorination of an Alcohol Using PyFluor[Product Highlights] PyFluor: A Stable Deoxyfluorinating Agent
Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Analytical Charts
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