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CAS RN: 18059-10-4 | Product Number: P2609
Peiminine
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Purity: >97.0%(HPLC)
Synonyms:
- Verticinone
- (3β,5α)-3,20-Dihydroxycevan-6-one
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$122.00
|
Contact Us | Contact Us | 14 |
|
| 50MG |
$426.00
|
1 | Contact Us | 18 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | P2609 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__4__3NO__3 = 429.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 18059-10-4 |
| Reaxys Registry Number | 96785 |
| PubChem Substance ID | 468592633 |
| Merck Index (14) | 4926 |
| MDL Number | MFCD00210542 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 97.0 area% |
| Specific rotation [a]20/D | -68.0 to -76.0 deg(C=0.5, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 137 °C |
| Specific Rotation | -72° (C=0.5,MeOH) |
| Maximum Absorption Wavelength | 288(EtOH) nm |
GHS
Related Laws:
| RTECS# | FL5795000 |
Transport Information:
| HS Number | 2939.79.0000 |
Application
Peiminine: A Bioactive Alkaloid with Antitussive, Expectorant and Anti-Inflammatory Activities
Peiminine (verticinone) and peimine (verticine) [P2610] are major active alkaloids isolated from the bulbs of Fritillaria ussuriensis, which is an Asian species of herbaceous plant in the lily family and a commonly used antitussive traditional Chinese medicinal (TCM) herb.1,2) It has been reported that peiminine and peimine also exhibit potent antitussive, expectorant and anti-inflammatory effects.3) In addition, peiminine can induce cancer cell apoptosis and autophagy.4,5) (The product is for research purpose only.)
References
- 1) Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection
- 2) Characterization and identification of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
- 3) Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae
- 4) Stabilizing parallel G-quadruplex DNA by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves
- 5) The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death
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