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CAS RN: 107133-36-8 | Product Number: P2968

Perindopril Erbumine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • Perindopril tert-Butylamine Salt
  • (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic Acid 2-Methyl-2-propanamine
  • (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid tert-Butylamine Salt
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Product Number P2968
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__9H__3__2N__2O__5·C__4H__1__1N = 441.61 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 107133-36-8
Reaxys Registry Number 4285797
MDL Number

MFCD02313824

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation -65.0 to -70.0 deg(C=1, ethanol)
NMR confirm to structure
Properties (reference)
Solubility in water Soluble
Solubility (soluble in) Ethanol
GHS
Related Laws:
RTECS# NL5999600
Transport Information:
HS Number 2933.99.9701
Application
Perindopril Erbumine: A Long Acting Angiotensin Converting Enzyme (ACE) Inhibitor

Perindopril erbumine (S-9490-3) is an oral prodrug ester of perindoprilat, an inhibitor of angiotensin converting enzyme (ACE), which effectively lowers blood pressure. ACE catalyzes conversion of the inactive decapeptide, angiotensin I, to the vasoconstrictor, angiotensin II. Angiotensin II is a potent peripheral vasoconstrictor, which stimulates aldosterone secretion by the adrenal cortex, and provides on renin secretion. ACE inhibitors, such as perindopril occupy the active center of the enzyme so that cleavage of angiotensin I is inhibited competitively. (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
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