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CAS RN: 13292-46-1 | Product Number: R0079

Rifampicin


Purity: >98.0%(T)
Synonyms:
  • Rifampin
  • Rifamycin AMP
Documents:
5G
$82.00
5   2   ≥100 
25G
$228.00
22   6   ≥100 

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Product Number R0079
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__4__3H__5__8N__4O__1__2 = 822.95 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Moisture Sensitive,Heat Sensitive
CAS RN 13292-46-1
Reaxys Registry Number 5723476
PubChem Substance ID 87560354
Merck Index (14) 8216
MDL Number

MFCD00151389

Specifications
Appearance Orange to Amber to Dark red powder to crystal
Purity(HPLC) min. 94.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
NMR confirm to structure
Properties (reference)
Melting Point 188 °C(dec.)
Solubility (soluble in) Dimethylformamide
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# VJ7000000
Transport Information:
HS Number 2941.90.3000
Application
Rifampicin: A Rifamycin Antibiotic with Activity against a Wide Variety of Organisms including Tuberculosis Germs

Rifampicin (other name: rifampin) is a semisynthetic rifamycin antibiotic, which is chemically synthesized from rifamycin, which is isolated from a strain of the actinomycete Amycolatopsis mediterranei. Rifampicin has activity against a wide variety of organisms, including tuberculosis germs and Staphylococcus aureus, as well as in vitro activity against penicillin-resistant Streptococcus pneumoniae, and many Gram-negative bacteria. Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase, which is responsible for DNA transcription. In contrast, the corresponding mammalian enzymes are not affected by rifampicin. Bacterial resistance to rifampicin is caused by mutations leading to a change in the structure of the β subunit of RNA polymerase. Rifampicin acts as a cytochrome P450 3A4 (CYP3A4) inducer, which increase the activity of CYP3A4. Thus, rifampicin can cause drug interaction with other medications.

References


PubMed Literature


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