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CAS RN: 53123-88-9 | Product Number: R0097
Rapamycin
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Purity: >98.0%(HPLC)
Synonyms:
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$244.00
|
2 | 7 | ≥20 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | R0097 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__5__1H__7__9NO__1__3 = 914.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | <0°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 53123-88-9 |
| Reaxys Registry Number | 5848501 |
| PubChem Substance ID | 160871302 |
| Merck Index (14) | 8114 |
| MDL Number | MFCD00867594 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 1.20 to 1.70 % |
| Specific rotation [a]20/D | -145 to -155 deg(C=0.2, MeOH) |
Properties (reference)
| Melting Point | 177 °C(dec.) |
| Specific Rotation | -150° (C=0.2,MeOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Chloroform,Acetone,Dimethylformamide,Methanol,Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H371 : May cause damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
Related Laws:
| RTECS# | VE6250000 |
Transport Information:
| HS Number | 2941.90.5000 |
Application
Studies of mTOR (mammalian target of rapamycin) Inhibition
References
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
- Defining the role of mTOR in cancer
- Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
- Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
- mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
PubMed Literature
Articles/Brochures
TCIMAIL
Documents
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