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CAS RN: 162401-32-3 | Product Number: R0193

Roflumilast


Purity: >98.0%(HPLC)
Synonyms:
  • 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Documents:
250MG
$69.00
1   Contact Us 24  
1G
$165.00
1   Contact Us 17  

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Product Number R0193
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__4Cl__2F__2N__2O__3 = 403.21 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Condition to Avoid Heat Sensitive
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image),  250MG-Glass Bottle with Plastic Insert (View image)
CAS RN 162401-32-3
Reaxys Registry Number 9802592
PubChem Substance ID 354334855
Merck Index (14) 8249
MDL Number

MFCD00938270

Specifications
Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 97.0 %
Melting point 157.0 to 161.0 °C
Properties (reference)
Melting Point 159 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Related Laws:
RTECS# CV3325600
Transport Information:
HS Number 2933.39.4100
Application
Roflumilast: A Selective Phosphodiesterase 4 (PDE4) Inhibitor.

R0193

Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor. The active metabolite, Roflumilast N-oxide [R0217], also acts as a selective PDE4 inhibitor. PDE4 is a key enzyme in the degradation of cyclic adenosine monophosphate (cyclic AMP) [A2381] and is centrally involved in the cytokine production of inflammatory cells. The inhibition of PDE4 activity leads to accumulation of intracellular cyclic AMP. Roflumilast is used for the treatment of chronic obstructive pulmonary disease (COPD). While the precise mechanism of the therapeutic action in COPD is not well defined, it is thought to be related to the effects of increased intracellular cyclic AMP in lung cells. For your reference, [C3395] and [D4505] are synthetic intermediates of roflumilast. (The product is for research purpose only.)

References


PubMed Literature


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