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CAS RN: 99755-59-6 | Product Number: R0220
Rotigotine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-6-[Propyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$135.00
|
1 | Contact Us | 3 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | R0220 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__5NOS = 315.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 99755-59-6 |
| Reaxys Registry Number | 5822772 |
| PubChem Substance ID | 468592791 |
| MDL Number | MFCD00869590 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -34.0 ～ -38.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 78 °C |
| Specific Rotation | -42.7° (C=1,MeOH) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 37.4 mg/l 25 °C |
| Solubility (soluble in) | Ethanol, Dimethylformamide |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | QK4252968 |
Transport Information:
| HS Number | 2934.99.3000 |
Application
Rotigotinei: A Non-Ergot Dopamine Receptor Agonist
Rotigotinei is a non-ergot dopamine receptor agonist. Rotigotinei is used as a curative medicine via a transdermal system for Parkinson's disease and restless legs syndrome. The precise mechanism of action of rotigotinei is unknown, although it is thought to be related to its ability to stimulate dopamine receptors. (The product is for research purpose only.)
References
- The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease
- Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors
- Rotigotine transdermal patch: a review of its use in the treatment of Parkinson's disease
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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