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CAS RN: 144-83-2 | Product Number: S0071
Sulfapyridine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(4-Aminobenzenesulfonamido)pyridine
- N'-2-Pyridylsulfanilide
- 2-Sulfanilamidopyridine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25G |
$51.00
|
18 | 15 | ≥60 |
|
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| Product Number | S0071 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__1N__3O__2S = 249.29 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 144-83-2 |
| Reaxys Registry Number | 222065 |
| PubChem Substance ID | 87575694 |
| SDBS (AIST Spectral DB) | 6899 |
| Merck Index (14) | 8938 |
| MDL Number | MFCD00038036 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 190.0 to 194.0 °C |
| Solubility in hot Acetone | almost transparency |
Properties (reference)
| Melting Point | 190 °C |
GHS
Related Laws:
| RTECS# | DA9625000 |
Transport Information:
| HS Number | 2935.90.9500 |
Application
Sulfapyridine: a synthetic sulfonamide antimicrobial with a wide spectrum
Sulfapyridine (or sulphapyridine) is a synthetic sulfonamide antimicrobial with a wide spectrum against most gram-positive and many gram-negative organisms. Sulfapyridine, as well as other sulfonamides, inhibits the bacterial enzyme dihydropteroate synthetase and multiplication of bacteria by acting as competitive inhibitors of 4-aminobenzoic acid in the folic acid metabolism cycle. Its water solubility is pH and co-solvent dependent. Meanwhile, sulfapyridine and 5-aminosalicylic acid [A0317] are known as the bacterial metabolites of sulfasalazine (sulphasalazine) [S0580]. (The product is for research purpose only.)
References
- Dapsone and sulfapyridine (a review)
- Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid (a review)
- Solubility of sulfapyridine in propylene glycol + water mixtures and correlation with the Jouyban-Acree model
- Thermodynamic study of the solubility of sulfapyridine in some ethanol + water mixtures
- A novel simultaneous HPLC assay for serum paracetamol and sulfapyridine as markers of gastric emptying and orocecal transit
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